Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst.
نویسندگان
چکیده
Continuing efforts to establish a more general "user-friendly" protocol for the palladium-catalysed arylation of amines (Buchwald-Hartwig reaction) are described herein. Significant advances have been made through the use of the versatile (SIPr)Pd(methallyl)Cl complex in conjunction with the reliable base lithium hexamethyldisilazide (LHMDS).
منابع مشابه
Efficient buchwald hartwig reaction catalyzed by spions-bis(NHC)-Pd(II)
A powerful and convenient reaction procedure for the C-N coupling reaction (the Buchwald-Hartwig reaction), yielding products of N-arylanilines and N-arylamines in both conventional heating and microwave irradiation has been reported. The protocol utilizes a stable and new supper ferromagnetic nanoparticle chelating N-heterocyclic dicarbene palladium(II) complex (Pd-NHC) as catalyst which helps...
متن کاملWell-defined, air-stable (NHC)Pd(Allyl)Cl (NHC = N-heterocyclic carbene) catalysts for the arylation of ketones.
A number of palladium-N-heterocyclic carbene (NHC) complexes were found to be active catalysts for the arylation of ketones. A large number of substrates, both aryl halides and ketones, are compatible with the reaction conditions. The ketone arylation reactions are achieved with low catalyst loading in short reaction times using aryl chlorides and triflates as reactive partners. [reaction: see ...
متن کاملSPION-A-Pd(EDTA) (superparamagnetic iron oxide nanoparticles-A-ethylendiamine tetraacetic acid) as a robust nanocatalyst for Buchwald-Hartwig C-N Coupling Reaction
During thelast20-30 years, palladium-catalyzed reactions have witnessed tremendous advances in the industrial and organic reactions such as hydrogenation, coupling, cyanation and amination. Despite the wide utility of Pd-catalysts in these reactions, they suffer from a number of drawbacks such as recovery, reuse of catalyst and remain as a contaminant in the products at the end of the reaction...
متن کاملExtending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles
The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C-H functionalization of sulfur- or nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % pal...
متن کاملSynthetic and structural studies on amine coordination to Pd-N-heterocyclic carbene complexes.
The reaction between 2-chlorobenzylamine or 2-chlorobenzylalcohol and Pd(I(t)Bu)(2) (I(t)Bu = 1,3-di-tert-butylimidazol-2-ylidene) in benzene affords the dimeric complexes [Pd(I(t)Bu)(mu-NH{2-CH(2)C(6)H(4)})](2) and [Pd(I(t)Bu)(mu-O{2-CH(2)C(6)H(4)})](2); the latter has been structurally characterised. The syntheses, structural characterisation and reactivity of the Pd-NHC amine complexes [(I(t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 6 15 شماره
صفحات -
تاریخ انتشار 2008